M E Chowdhury Shameem was born in Dhaka. He studied at Dhaka College, the Department of English at Dhaka University, Charles University in Prague, and the State University of New York, USA. From 1996 to 2004, he worked at IBM Corporation in New York, USA.

In 2005, he founded MARS Solutions Limited, an IT/ITES company. As the Founder and Managing Director, he has made significant contributions to the IT sector. He is also a founding member of the Bangladesh Semiconductor Industry Association (BSIA) and was elected Senior Vice President for the 2024-2027 term. He further served as a Director of the Bangladesh Association of Call Center & Outsourcing (BACCO). In addition, he serves as the current CEO of NRB Job Ltd. and was formerly the Founder and CEO of Prothom Alo Job.

Alongside his entrepreneurial ventures, Chowdhury is a well-known social worker. Upon returning to Bangladesh in 2004, he launched a lifelong dream project—Ethics Club Bangladesh Society, aimed at promoting ethical values across all walks of life. Today, the club operates units nationwide and organizes educational programs throughout the year. He has also founded several socio-cultural organizations, and currently serves as the Founder and President of the Scholars Bangladesh Society, the Center for NRB Foundation, the NRB-PBO Club Limited, the NRB-PBO Conference Dhaka, NS Publishers, and the School of Performing Arts in New York.

Chowdhury organized the NRB-PBO Conferences for the first time in Dhaka in 2005, 2007, and 2009 to connect Non-Resident Bangladeshis and People of Bangladeshi Origin for the country's development. The 2007 and 2009 conferences were held in strategic partnership with the Ministry of Foreign Affairs, Government of the People's Republic of Bangladesh. He also organized the first NRB-PBO Literature and Culture Conference in 2024, supported by Bangla Academy. His tireless advocacy for NRBs led the Government of Bangladesh to declare 30 December as Jatio Probashi Dibosh (NRB Day), a national day of the country.

Beyond technology and community service, Chowdhury is a globally recognized manga writer, winning the Bronze Medal in the 17th International Manga Competition, organized by the Government of Japan in 2023. He is also an accomplished writer, columnist, and publisher. An IT specialist by profession, Chowdhury is widely recognized for his active role in promoting Bengali culture worldwide. His leadership and dedication have earned him multiple accolades, including Proclamation from THE COUNCIL CITY OF NEW YORK in 2004 for his outstanding service to the Bangladeshi community. He is also a life member of Bangla Academy.